B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005
Research Interests
I am interested in developing and applying statistical methods to identify
genetic factors influencing complex traits. I participate in collaborative
research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes,
abdominal aortic aneurysm, age-related macular degeneration and phenotype severity
in cystic fibrosis. I am involved in the Human Genetic Analysis Resourse (H.G.A.R.),
a collaborative project that develops statistical methods to analyze genetic data with
an eye toward localizing genetic variants that cause disease, and that implements these approaches
in the Statistical Analysis for Genetic Epidemiology (S.A.G.E.) software package.
Professional Memberships
American Society of Human Genetics
International Genetic Epidemiology Society
Courses Taught
EPBI 452: Statistical Methods for Genetic Epidemiology
Recent Publications
Sinha, R., Igo, R. P., Jr., Saini, S. K., Elston, R. C. and Luo, Y. (2009). Bayesian intervals for linkage
locations. Genet. Epidemiol., in press.
Igo, R. P., Jr., Li, J. and Goddard, K. A. B. (2009). Association mapping by generalized linear regression with
density-based haplotype clustering. Genet. Epidemiol., 33, 16-26.
Arar, N. H., Freedman, B. I., Adler, S. G., Iyengar, S. K., Chew, E. Y., Davis, M. D., Satko,
S. G., Bowden, D. W., Duggirala, R., Elston, R. C., Guo, X., Hanson, R. L., Igo, R. P., Jr.,
et al. (2008). Heritability of the severity of diabetic retinopathy: the FIND-Eye study.
Invest. Ophthalmol. Vis. Sci.49, 3839-3845.
Brkanac, Z., Chapman, N. H., Igo, R. P., Jr., Matsushita, M. M., Nielsen, K., Berninger, V. W.,
Wijsman, E. M. and Raskind, W. H. (2008). Genome scan of a nonword repetition phenotype in families
with dyslexia: evidence for multiple loci.
Behav. Genet.38, 462-475.
Igo, R. P., Jr. and Wijsman, E. M. (2008). Empirical significance values for linkage analysis: trait simulation using
posterior model distributions from MCMC oligogenic segregation analysis.
Genet. Epidemiol.32, 119-131.
Igo, R. P., Jr., Londono, D., Miller, K., Parrado, A. R., Quade, S. R. E., Sihna, M., Kim, S., Won, S., Li, J., and
Goddard, K. A. B. (2007). Density-based clustering in haplotype analysis for association mapping.
BMC Proc.1 (Suppl 1), S27.
Bickeböller, H., Goddard, K. A. B., Igo, R. P., Jr., Kraft, P., Lozano, J. P., and Pankratz, N. (2007).
Issues in association mapping with high-density SNP data and diverse family structures.
Genet. Epidemiol.31 (Suppl 1), S22-S33.
Igo, R. P., Jr., Chapman, N. H., and Wijsman, E. M. (2006). Segregation analysis of a complex quantitative trait:
approaches for identifying influential data points.
Hum. Hered.61, 80-86.
Igo, R. P., Jr., Chapman, N. H., Thomson, J. B., Berninger, V. W.,
Matsushita, M., Brkanac, Z., Holzman, T., Raskind, W. H.,
and Wijsman, E. M. (2006). Genomewide scan for real-word reading subphenotypes of dyslexia:
novel chromosome 13 locus and genetic complexity.
Am. J. Med. Genet. (Neuropsychiatr. Genet.)141, 15-27.
