case western reserve university



Rob Igo, Ph.D.

Visiting Instructor, Division of Genetic & Molecular Epidemiology

Genetic epidemiology of complex diseases, development of genetic analysis software

Office: Wolstein Research Bldg., Room 1302
Phone: (216) 368-4562
B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005

Research Interests
I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, abdominal aortic aneurysm, age-related macular degeneration and phenotype severity in cystic fibrosis. I am involved in the Human Genetic Analysis Resourse (H.G.A.R.), a collaborative project that develops statistical methods to analyze genetic data with an eye toward localizing genetic variants that cause disease, and that implements these approaches in the Statistical Analysis for Genetic Epidemiology (S.A.G.E.) software package.

Professional Memberships
American Society of Human Genetics
International Genetic Epidemiology Society

Courses Taught
EPBI 452: Statistical Methods for Genetic Epidemiology

Recent Publications

Wijsman EM, Rothstein JH, Igo RP Jr, Brunzell JD, Motulsky AG and Jarvik GP (2010). Linkage and association analysis identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families. Hum. Genet. 127, 705-719.

Igo RP Jr, Luo Y and Li S (2010). Markov chain Monte Carlo linkage analysis: methods and software packages. In Handbook on Analyzing Human Genetic Data: Computational Approaches and Software, Springer-Verlag, New York, in press.

Malhotra A, Igo RP Jr,, Thameem F, Kao WHL, Abboud HE, Adler SG, Arar NH, Bowden DW, Duggirala R, Freedman BI et al. (2009). Genome-wide linnkage scans for type 2 diabetes mellitus in four ethnically diverse populations: significant evidence for linkage on chromosome 4q in African Americans. Diabetes Metab. 25, 740-747.

Sinha R, Igo RP Jr, Saini SK, Elston RC and Luo Y (2009). Bayesian intervals for linkage locations. Genet. Epidemiol. 33, 604-616.

Igo RP Jr, Li J and Goddard KAB (2009). Association mapping by generalized linear regression with density-based haplotype clustering. Genet. Epidemiol., 33, 16-26.

Arar NH, Freedman BI, Adler SG, Iyengar SK, Chew EY, Davis MD, Satko SG, Bowden DW, Duggirala R, Elston RC, Guo X, Hanson RL, Igo RP Jr et al. (2008). Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest. Ophthalmol. Vis. Sci. 49, 3839-3845.

Brkanac Z, Chapman NH, Igo RP Jr, Matsushita MM, Nielsen K, Berninger VW, Wijsman EM and Raskind WH (2008). Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple loci. Behav. Genet. 38, 462-475.

Igo RP Jr and Wijsman EM (2008). Empirical significance values for linkage analysis: trait simulation using posterior model distributions from MCMC oligogenic segregation analysis. Genet. Epidemiol. 32, 119-131.

Igo RP Jr, Londono D, Miller K, Parrado AR, Quade SRE, Sihna M, Kim S, Won S, Li J and Goddard KAB (2007). Density-based clustering in haplotype analysis for association mapping. BMC Proc. 1 (Suppl 1), S27.

Bickeböller, H., Goddard, K. A. B., Igo, R. P., Jr., Kraft, P., Lozano, J. P., and Pankratz, N. (2007). Issues in association mapping with high-density SNP data and diverse family structures. Genet. Epidemiol. 31 (Suppl 1), S22-S33.

Igo RP Jr, Chapman NH and Wijsman EM (2006). Segregation analysis of a complex quantitative trait: approaches for identifying influential data points. Hum. Hered. 61, 80-86.

Igo RP Jr, Chapman NH, Thomson JB, Berninger VW, Matsushita M, Brkanac Z, Holzman T, Raskind WH and Wijsman EM (2006). Genomewide scan for real-word reading subphenotypes of dyslexia: novel chromosome 13 locus and genetic complexity. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 141, 15-27.

Additional Links

Last Updated: December 31, 2008